Nonapeptide-1 – Research & Cosmetic Peptide Overview

Nonapeptide-1 is a synthetic nine-amino-acid peptide widely studied in cosmetic and peptide research, particularly in relation to melanogenesis, pigmentation signaling, and skin-tone appearance. It is also known as Melanostatine-5 and has the CAS number 158563-45-2. PubChem lists its sequence as MPFRWFKPV and molecular weight at approximately 1,206.5 g/mol. nonapeptide 1​

What Is Nonapeptide-1?

Nonapeptide-1 is a synthetic peptide associated with research into the α-MSH/MC1R signaling pathway, which plays an important role in melanin production. Research and cosmetic ingredient references describe Nonapeptide-1 as an ingredient investigated for its potential to modulate pigmentation-related processes.

Because of this mechanism, Nonapeptide-1 has become an ingredient of interest in formulations and research involving uneven skin tone, visible pigmentation, and skin-brightening applications.

How Nonapeptide-1 Works

Nonapeptide-1 has been studied as an antagonist of the melanocortin-1 receptor (MC1R), a receptor involved in signaling that regulates melanin production. By interacting with this pathway, researchers investigate how Nonapeptide-1 may influence melanogenesis.

This makes the peptide particularly relevant to research into:

• Melanin synthesis
• Melanogenesis signaling
• MC1R-related pathways
• Skin pigmentation
• Uneven skin tone
• Cosmetic peptide formulations
• Skin-brightening ingredient research

Nonapeptide-1 and Skin Research

Nonapeptide-1 has a growing research profile in pigmentation science. Cosmetic ingredient references identify it as a synthetic peptide used in products designed around skin conditioning and tone-evening objectives.

Recent peptide research also continues to investigate nonapeptides and related signaling pathways involved in pigmentation. A 2026 study, for example, identified another nonapeptide, AOP-P1, and investigated its effects on melanogenesis through the NPR2/cGMP/PKG/MITF pathway. This demonstrates the continuing scientific interest in nonapeptides as molecular tools for pigmentation research, although AOP-P1 is not the same compound as Nonapeptide-1.

Nonapeptide-1 Research Applications

Researchers and cosmetic scientists may investigate Nonapeptide-1 in areas including:

• Melanogenesis research
• Pigmentation biology
• MC1R signaling
• α-MSH pathway research
• Cosmetic peptide development
• Skin-tone research
• Dark-spot and pigmentation formulation research
• Peptide–receptor interactions

Why Choose Nonapeptide-1 for Research?

Nonapeptide-1 provides researchers with a defined synthetic peptide for investigating pigmentation-related signaling. Its well-characterized chemical identity and established sequence make it useful for laboratory characterization and formulation research.

Where to buy Nonapeptide-1

If you’re wondering where to buy Nonapeptide-1 , it’s important to choose a reputable supplier that provides high-quality products, third-party testing, and transparent information about purity and manufacturing standards. Nonapeptide-1

PeptaShop is a trusted online store for purchasing Nonapeptide-1 offering high-quality products, transparent sourcing, and a commitment to customer satisfaction.

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